Nearly eight years after she vanished, speculation about the fate of missing Alabama high school graduate Natalee Holloway continues. Most believe she is dead while others claim that she lives on in slavery. The mystery surrounding her disappearance has proved an enduring one that continues to draw professional and amateur sleuths alike.

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On May 6, 2013, three young women were rescued from a home in Cleveland, Ohio. One of the girls, 26-year-old Amanda Berry, went missing more than a decade ago. Her grieving mother won’t get to reunite with her daughter. She died two years after so-called psychic Sylvia Browne told her that Amanda was dead.

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Eight-year-old Kyron Horman has been missing since June 4, 2010. Investigators focused on his stepmother, Terri Moulton Horman, but no suspects have been named and the case remains unsolved.

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When Joshua Rubin disappeared on Halloween in 2011, the Brooklyn café owner’s friends and family mounted a frantic effort to find him, and the media joined in. Worried that he was lost and needed his medication, these concerned parties revealed his private medical information; open rumors about his financial problems and alleged involvement with drugs soon followed.

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Shortly after his 18th birthday, Lee Cutler disappeared. He left a friend’s house after a sleepover and never arrived at work. A series of clues found after Lee vanished suggested that Lee may have gone off to live in the woods, or committed suicide, but despite several sightings, what happened to Lee remains a mystery.

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When a child is missing–and later found murdered–authorities often don’t have to look far from the home to find a suspect.

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Having a body is normally step one in prosecuting a murder case, but authorities in St. Paul believe they have enough evidence–including “copious amounts” of blood–to charge Jeffrey Trevino in the death of his wife Kira, 30, although her remains have not been located.

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A 30-year-old St. Paul, Minn., woman is missing. Kira Trevino worked as manager of a Delia’s clothing store at the Mall of America. Close friend and co-worker Tara Hall told the Minneapolis Star Tribune that Trevino had left her Iowa avenue home but never made it to work Friday.

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Police and friends are searching for Los Angeles, Calif., woman Lacey Brooks, who has been missing since November 29, 2012. She was last seen leaving her father’s home in the Downey area of Los Angeles at 10:30 a.m., saying she was going for a walk. She left her cell phone, wallet and her dog behind.

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The transgender teen has been missing from Charlottesville, Virginia since before Thanksgiving and was last seen on the 500 block of West Main Street. DaShad occasionally cross dresses and may go by the names Sage, Sagey or Unique.

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